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Can I read Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1–associated myelopathy/tropical spastic paraparesis on EtoBox?
Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1–associated myelopathy/tropical spastic paraparesis by Misako Nagasaka; Makoto Yamagishi; Naoko Yagishita; Natsumi Araya; Seiichiro Kobayashi; Junya Makiyama; Miyuki Kubokawa; Junji Yamauchi; Daisuke Hasegawa; Ariella L. G. Coler-Reilly; Shuntaro Tsutsumi; Yu Uemura; Ayako Arai; Ayako Takata; Eisuke Inoue; Yasuhiro Hasegawa; Toshiki Watanabe; Yutaka Suzuki; Kaoru Uchimaru; Tomoo Sato; Yoshihisa Yamano is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1–associated myelopathy/tropical spastic paraparesis about?
## Significance HTLV-1 manifests many diseases, which cause morbidity and mortality in 5∼10% of infected individuals, including the fatal adult T cell leukemia/lymphoma (ATLL) and debilitating myelopathy (HAM/TSP). However, the rarity of these diseases had made it prohibitory to conduct large-scale prospective observational studies. This work enabled calculating the standard mortality ratio of HAM/TSP patients and also identified ATLL as one of the major causes of death among these patients. We also identified the features that lead HAM/TSP patients to develop ATLL: having dominant clonal expansion of HTLV-1–infected cells with ATLL-associated somatic mutations. Furthermore, this manuscript describes genomic changes occurring in HAM/TSP patients at the actual time of their ATLL transformation.
Who reads Mortality and risk of progression to adult T cell leukemia/lymphoma in HTLV-1–associated myelopathy/tropical spastic paraparesis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Misako Nagasaka; Makoto Yamagishi; Naoko Yagishita; Natsumi Araya; Seiichiro Kobayashi; Junya Makiyama; Miyuki Kubokawa; Junji Yamauchi; Daisuke Hasegawa; Ariella L. G. Coler-Reilly; Shuntaro Tsutsumi; Yu Uemura; Ayako Arai; Ayako Takata; Eisuke Inoue; Yasuhiro Hasegawa; Toshiki Watanabe; Yutaka Suzuki; Kaoru Uchimaru; Tomoo Sato; Yoshihisa Yamano
- Publisher
- Proceedings of the National Academy of Sciences
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)