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Fy Phenotype and Gender Determine Plasma Levels of Monocyte Chemotactic Protein by Petra Jilma‐Stohlawetz; Monika Homoncik; Christa Drucker; Claudia Marsik; Antal Rot; Wolfgang R. Mayr; Brigitte Seibold; Bernd Jilma is a Medicine article available to read on EtoBox.

What is Fy Phenotype and Gender Determine Plasma Levels of Monocyte Chemotactic Protein about?

**BACKGROUND:** In vitro studies indicate that the Fy blood group system antigens serve as receptors for chemokines such as monocyte chemotactic protein‐1 (MCP‐1) and RANTES. However, it is unclear whether subjects with the Fy(a−b−) phenotype exhibit altered clearance and hence altered plasma levels of chemo‐kines, because they still express Fy on endothelial cells. **STUDY DESIGN AND METHODS:** To clarify a possible in vivo role of Fy on RBCs in the regulation of chemo‐kine levels, healthy young volunteers of common Fy phenotypes were compared in a cross‐sectional study. **RESULTS:** More than 90 percent of the 34 subjects of African origin were Fy(a−b−), one black volunteer was Fy(a+b−), and two were Fy(a−b+). As expected, all 65 white volunteers were positive for either Fy^a^ and/or Fy^b^. Unexpectedly, persons expressing either Fy^a^ and/or Fy^b^ had significantly higher plasma levels of MCP‐1 than Fy(a−b−) volunteers (women: 154 vs. 110 ng/L, p<0.01; men: 179 vs. 169 ng/L, p = 0.03). Surprisingly, plasma levels of MCP‐1 were found to be sex‐dependent: median MCP‐1 levels averaged 180 ng per L in men but only 139 ng per L in women (p<0.001). Further, MCP‐1 levels decreased sign

Who reads Fy Phenotype and Gender Determine Plasma Levels of Monocyte Chemotactic Protein?

Author

Petra Jilma‐Stohlawetz; Monika Homoncik; Christa Drucker; Claudia Marsik; Antal Rot; Wolfgang R. Mayr; Brigitte Seibold; Bernd Jilma

Publisher

Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)

Published

2001

Language

EN

Field

Medicine (Health Sciences)