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Enhanced Cell Affinity of Poly (D,l-lactide) by Combining Plasma Treatment with Collagen Anchorage by Jian Yang; Jianzhong Bei; Shenguo Wang is a Engineering article available to read on EtoBox.

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Surface properties of poly (d,l-lactide) (PDLLA) were modified by combining plasma treatment and collagen modification. The changes of surface properties were characterized by contact angles, surface energy, X-ray photoelectron spectra and scanning electron microscopy. The mouse 3T3 fibroblasts were used as model cells to evaluate the cell affinity of PDLLA before and after modification. Effects of different modification methods including plasma treatment, collagen coating and combining plasma treatment with collagen anchorage were investigated and compared. The results showed that the hydrophilicity and surface-free energy were improved and reduced, respectively, after each modification. Plasma pre-treatment could improve the roughness as it incorporated the polar groups and positively charged groups onto the sample surface; so the plasma pre-treated surface would benefit in anchoring more collagen tightly. As a result, cell affinity of PDLLA modified by combining plasma treatment with collagen anchorage was greatly improved. The modified materials could endure rinsing by PBS, which would facilitate further application when the modified materials were used as cells scaffold in tis

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Author

Jian Yang; Jianzhong Bei; Shenguo Wang

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2002

Language

EN

Field

Engineering (Physical Sciences)