Opening book details…
Can I read Phage Against the Machine: Discovery and Mechanism of Type V Anti-CRISPRs on EtoBox?
Phage Against the Machine: Discovery and Mechanism of Type V Anti-CRISPRs by Nicole D. Marino is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Phage Against the Machine: Discovery and Mechanism of Type V Anti-CRISPRs about?
The discovery of diverse bacterial CRISPR-Cas systems has reignited interest in understanding bacterial defense pathways while yielding exciting new tools for genome editing. CRISPR-Cas systems are widely distributed in prokaryotes, found in 40% of bacteria and 90% of archaea, where they function as adaptive immune systems against bacterial viruses (phage) and other mobile genetic elements. In turn, phage have evolved inhibitors, called anti-CRISPR proteins, to prevent targeting. Type V CRISPR-Cas12 systems have emerged as a particularly exciting arena in this co-evolutionary arms race. Type V anti-CRISPRs have highly diverse and novel mechanisms of action, some of which appear to be unusually potent or widespread. In this review, we discuss the discovery and mechanism of these anti-CRISPRs as well as future areas for exploration.
Who reads Phage Against the Machine: Discovery and Mechanism of Type V Anti-CRISPRs?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Nicole D. Marino
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)