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Whole Genome Non-invasive Prenatal Testing in Prenatal Screening Algorithm: Clinical Experience from 12,700 Pregnancies by Elena E. Baranova; Olesya V. Sagaydak; Alexandra M. Galaktionova; Ekaterina S. Kuznetsova; Madina T. Kaplanova; Maria V. Makarova; Maxim S. Belenikin; Anton S. Olenev; Ekaterina N. Songolova is a Medicine article available to read on EtoBox.
What is Whole Genome Non-invasive Prenatal Testing in Prenatal Screening Algorithm: Clinical Experience from 12,700 Pregnancies about?
## Background: A fast adoption of a non-invasive prenatal testing (nipt) in clinical practice is a global tendency last years. firstly, in russia according a new regulation it was possible to perform a widescale testing of pregnant women in chromosomal abnormality risk. the aim of the study-to assess efficiency of using nipt as a second-line first trimester screening test in moscow. ## Methods: Based on the first trimester combined prenatal screening results 12,700 pregnant women were classified as a high-risk (cut-off ≥ 1:100) and an intermediate-risk (cut-off 1:101 - 1:2500) groups followed by whole genome nipt. women from high-risk group and those who had positive nipt results from intermediate-risk group were considered for invasive prenatal diagnostic. ## Results: 258 (2.0%) samples with positive nipt results were detected including 126 cases of trisomy 21 (t21), 40 cases of t18, 12 cases of t13, 41 cases of sex chromosome aneuploidies (scas) and 39 cases of rare autosomal aneuploidies (raas) and significant copy number variations (cnvs). statistically significant associations (p < 0.05) were revealed for fetal fraction (ff) and both for some patient's (body mass index and wei
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- Author
- Elena E. Baranova; Olesya V. Sagaydak; Alexandra M. Galaktionova; Ekaterina S. Kuznetsova; Madina T. Kaplanova; Maria V. Makarova; Maxim S. Belenikin; Anton S. Olenev; Ekaterina N. Songolova
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)