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INTRODUCTION: For many years, we have used therapeutic hypothermia (48-72 hr) in patients with severe traumatic brain injury (Glasgow Coma Scale scores of 5 or less). In 2000, we altered the target temperature to 35°C from the former 33°C, as our findings suggested that cooling to 35°C is sufficient to control intracranial hypertension and that hypothermia below 35°C may predispose patients to persistent cumulative oxygen debt, which may be associated with an increased risk of complications. In this study, we attempted to clarify whether 35°C hypothermia has the same effect as 33°C hypothermia in reducing intracranial hypertension and whether it is associated with fewer complications and improved outcomes. METHODS: We compared intracranial pressure and biochemical parameters of the 30 patients treated with 35°C hypothermia (January 2000-June 2005) with those of the 31 patients treated with 33°C hypothermia (July 1994-December 1999). RESULTS: Patient characteristics were similar in the two groups. The mean intracranial pressure on Days 1 to 7 after injury were 15.3 Ϯ 9.6 to 20.1 Ϯ 9.0 mmHg in the 35°C hypothermia group and 14.9 Ϯ 10.2 to 20.7 Ϯ 12.7 mmHg in the 33°C hypothermia grou

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Author

Manuel Ferreira; Scott L. Pomeroy

Publisher

Lippincott Williams and Wilkins; Oxford University Press; Lippincott Williams & Wilkins Ltd.; Oxford University Press (OUP); Ovid Technologies (Wolters Kluwer Health) (ISSN 0148-396X)

Published

2006

Language

EN

Field

Medicine (Health Sciences)