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The role of immunoglobulin G and fibrinogen in platelet aggregation by Streptococcus sanguis by I. Ford; C. W. I. Douglas; D. Cox; D. G. C. Rees; J. Heath; F. E. Preston is a Medicine article available to read on EtoBox.

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Previous work has shown that the type strain of __Streptococcus sanguis__, NCTC 7863, induces aggregation of normal platelets by a complement‐dependent mechanism. We investigated the roles of IgG and fibrinogen in the aggregation process. Plasma depleted of IgG by passage through protein A–sepharose failed to support platelet aggregation, as did plasma absorbed at 0°C with whole bacteria. However, absorption of plasma with a non‐aggregating strain of __S. sanguis__, SK96, did not remove aggregating activity for NCTC 7863. Supplementing 0°C‐absorbed plasma with purified IgG restored the aggregation supporting activity. A monoclonal antibody to the FcγRII receptor inhibited platelet aggregation by the bacteria, indicating a requirement for bacteria–IgG complexes interacting with the Fc receptor in platelet aggregation. There was a lag time to the onset of platelet aggregation of 7–19 min depending upon the platelet donor, but the length of this lag did not correlate with either total IgG concentration recognizing NCTC 7863 in subjects’ plasma, or the concentration any of the four IgG subclasses or with IgG avidity levels. Fibrinogen was shown to bind rapidly to the bacterial cell sur

Who reads The role of immunoglobulin G and fibrinogen in platelet aggregation by Streptococcus sanguis?

Author

I. Ford; C. W. I. Douglas; D. Cox; D. G. C. Rees; J. Heath; F. E. Preston

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

1997

Language

EN

Field

Medicine (Health Sciences)