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A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bug Cimex lectularius by Chloé Haberkorn; Jean-Philippe David; Hélène Henri; Jean-Marie Delpuech; Romain Lasseur; Fabrice Vavre; Julien Varaldi is a scholarly article available to read on EtoBox.

What is A major 6 Mb superlocus is involved in pyrethroid resistance in the common bed bug Cimex lectularius about?

In the last few years, the bed bug__Cimex lectularius__has been an increasing problem world-wide, mainly due to the development of insecticide resistance to pyrethroids. The characterization of resistance alleles is a prerequisite to improve surveillance and resistance management. To identify genomic variants associated with pyrethroid resistance in__Cimex lectularius__, we compared the genetic composition of two recent and resistant populations with that of two ancientsusceptible strains using a genome-wide pool-seq design. We identified a large 6 Mb “superlocus” showing particularly high genetic differentiation and association with the resistance phenotype. This superlocus contained several clustered resistance genes, and was also characterized by a high density of structural variants (inversions, duplications). The possibility that this superlocus constitutes a resistance “supergene” that evolved after the clustering of alleles adapted to insecticide and after reduction in recombination is discussed.

Author

Chloé Haberkorn; Jean-Philippe David; Hélène Henri; Jean-Marie Delpuech; Romain Lasseur; Fabrice Vavre; Julien Varaldi

Publisher

Cold Spring Harbor Laboratory

Published

2023

Language

EN