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Can I read Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling on EtoBox?

Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling by Wang, GuoYan (author);Qin, SenLin (author);Chen, Lei (author);Geng, HuiJun (author);Zheng, YiNing (author);Xia, Chao (author);Yao, JunHu (author);Deng, Lu (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling about?

Evidence shows that short-chain fatty acids (SCFAs) play an important role in health maintenance and disease development. In particular, butyrate is known to induce apoptosis and autophagy. However, it remains largely unclear whether butyrate can regulate cell ferroptosis, and the mechanism by which has not been studied. In this study, we found that RAS-selective lethal compound 3 (RSL3)- and erastin-induced cell ferroptosis were enhanced by sodium butyrate (NaB). With regard to the underlying mechanism, our results showed that NaB promoted ferroptosis by inducing lipid ROS production via downregulating the expression of solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4). Moreover, the FFAR2-AKT-NRF2 axis and FFAR2-mTORC1 axis accounts for the NaB-mediated downregulation of SLC7A11 and GPX4, respectively, in a cAMP-PKA-dependent manner. Functionally, we found that NaB can inhibit tumor growth and the inhibitory effect could be eliminated by administrating MHY1485 (mTORC1 activator) and Ferr-1 (ferroptosis inhibitor). Altogether, in vivo results suggest that NaB treatment is correlated to the mTOR-dependent ferroptosis and consequent tumor growth through

Who reads Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Wang, GuoYan (author);Qin, SenLin (author);Chen, Lei (author);Geng, HuiJun (author);Zheng, YiNing (author);Xia, Chao (author);Yao, JunHu (author);Deng, Lu (author)
Publisher
Springer Science and Business Media LLC
Published
2023
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

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