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Tuning Chemotactic Responses with Synthetic Multivalent Ligands by Jason E Gestwicki; Laura E Strong; Laura L Kiessling is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Tuning Chemotactic Responses with Synthetic Multivalent Ligands about?

Background: Multivalent ligands have been used previously to investigate the role of ligand valency and receptor clustering in eliciting biological responses. Studies of multivalent ligand function, however, typically have employed divalent ligands or ligands of unde¢ned valency. How cells respond to multivalent ligands of distinct valencies, which can cluster a signaling receptor to different extents, has never been examined. The chemoreceptors, which mediate chemotactic responses in bacteria, are localized, and clustering has been proposed to play a role in their function. Using multivalent ligands directed at the chemoreceptors, we hypothesized that we could exploit ligand valency to control receptor occupation and clustering and, ultimately, the cellular response. Results: To investigate the effects of ligand valency on the bacterial chemotactic response, we generated a series of linear multivalent arrays with distinct valencies by ring-opening metathesis polymerization. We report that these synthetic ligands elicit bacterial chemotaxis in both Escherichia coli and Bacillus subtilis. The chemotactic response depended on the valency of the ligand; the response of the bacteria ca

Who reads Tuning Chemotactic Responses with Synthetic Multivalent Ligands?

Author

Jason E Gestwicki; Laura E Strong; Laura L Kiessling

Publisher

Elsevier Science; Elsevier ; Cell Press; Elsevier BV (ISSN 1074-5521)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)