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Assessing regulatory features of the current transcriptional network of Saccharomyces cerevisiae by Monteiro, Pedro T.; Pedreira, Tiago; Galocha, Monica; Teixeira, Miguel C.; Chaouiya, Claudine is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Assessing regulatory features of the current transcriptional network of Saccharomyces cerevisiae about?

## Abstract The capacity of living cells to adapt to different environmental, sometimes adverse, conditions is achieved through differential gene expression, which in turn is controlled by a highly complex transcriptional network. We recovered the full network of transcriptional regulatory associations currently known for Saccharomyces cerevisiae, as gathered in the latest release of the YEASTRACT database. We assessed topological features of this network filtered by the kind of supporting evidence and of previously published networks. It appears that in-degree distribution, as well as motif enrichment evolve as the yeast transcriptional network is being completed. Overall, our analyses challenged some results previously published and confirmed others. These analyses further pointed towards the paucity of experimental evidence to support theories and, more generally, towards the partial knowledge of the complete network.

Who reads Assessing regulatory features of the current transcriptional network of Saccharomyces cerevisiae?

Author

Monteiro, Pedro T.; Pedreira, Tiago; Galocha, Monica; Teixeira, Miguel C.; Chaouiya, Claudine

Publisher

Springer Science and Business Media LLC; London: Nature Publishing Group; [London]: Springer Nature; Nature Publishing Group; Society for Mining, Metallurgy and Exploration Inc.; Research Square; Springer Nature; Island Press (ISSN 2045-2322)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)