Can I read Lamin Expression in Normal Human Skin, Actinic Keratosis, Squamous Cell Carcinoma and Basal Cell Carcinoma on EtoBox?

Lamin Expression in Normal Human Skin, Actinic Keratosis, Squamous Cell Carcinoma and Basal Cell Carcinoma by C.M.L.J. Tilli; F.C.S. Ramaekers; J.L.V. Broers; C.J. Hutchison; H.A.M. Neumann is a Medicine article available to read on EtoBox.

What is Lamin Expression in Normal Human Skin, Actinic Keratosis, Squamous Cell Carcinoma and Basal Cell Carcinoma about?

## Background: Aberrant expression patterns of nuclear lamins have been described in various types of cancer depending on the subtype of cancer, its aggressiveness, proliferative capacity and degree of differentiation. in general, the expression of a-type lamins (lamins a and c) has been correlated with a non-proliferating, differentiated state of cells and tissues. ## Objectives: To establish and compare the expression patterns of lamins in normal human skin, actinic keratosis (ak), squamous cell carcinoma (scc) and basal cell carcinoma (bcc). ## Methods: Expression patterns of the individual lamin subtypes were studied immunohistochemically. the proliferation capacity of the tumour cells was detected using a specific antibody to ki-67, and was related to the a-type lamin expression patterns. ## Results: In normal skin, lamin a was expressed in the suprabasal cell compartment of the epidermis, whereas the basal cells were mostly unstained. bccs and sccs stained positive in most cells, while the epidermis overlying bcc and scc and the epidermis in ak stained homogeneously and strongly in the basal cells in addition to the suprabasal cells. lamin c was expressed in some basal cells

Who reads Lamin Expression in Normal Human Skin, Actinic Keratosis, Squamous Cell Carcinoma and Basal Cell Carcinoma?

Author

C.M.L.J. Tilli; F.C.S. Ramaekers; J.L.V. Broers; C.J. Hutchison; H.A.M. Neumann

Publisher

Oxford University Press (OUP)

Published

2003

Language

EN

Field

Medicine (Health Sciences)