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Interleukin-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia by Yang Peng; Xiaofang Wang; Hong Wang; Wenchun Xu; Kaifeng Wu; Xuemei Go; Yibing Yin; Xuemei Zhang is a Immunology and Microbiology article available to read on EtoBox.
What is Interleukin-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia about?
## Abstract Streptococcus pneumoniae co-infection post-influenza is a major cause of mortality characterized by uncontrolled bacteria burden and excessive immune response during influenza pandemics. Interleukin (IL)-4 is a canonical type II immune cytokine known for its wide range of biological activities on different cell types. It displays protective roles in numerous infectious diseases and immune-related diseases, but its role in influenza and S. pneumoniae (influenza/S. pneumoniae) co-infected pneumonia has not been reported. In our study, we used C57BL/6 wild-type (WT) and IL-4-deficient (IL-4−/−) mice to establish co-infection model with S. pneumoniae after influenza virus infection. Co-infected IL-4−/− mice showed increased mortality and weight loss compared with WT mice. IL-4 deficiency led to increased bacterial loads in lungs without altering influenza virus replication, suggesting a role of IL-4 in decreasing post-influenza susceptibility to S. pneumoniae co-infection. Loss of IL-4 also resulted in aggravated lung damage together with massive proinflammatory cytokine production and immune cell infiltration during co-infection. Administration of recombinant IL-4 rescued
Who reads Interleukin-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Yang Peng; Xiaofang Wang; Hong Wang; Wenchun Xu; Kaifeng Wu; Xuemei Go; Yibing Yin; Xuemei Zhang
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)