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Improved Antitumor Outcomes for Colon Cancer Using Nanomicelles Loaded with the Novel Antitumor Agent LA67 by Minhu Cui; Mingji Jin; Mingfeng Han; Yingda Zang; Chuangjun Li; Dongming Zhang; Wei Huang; Zhonggao Gao; Xuezhe Yin is a Materials Science article available to read on EtoBox.

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## Background LA67 is a derivative of triptolide that exhibits strong antitumor activity. This derivative has a better safety profile than triptolide, but is limited by poor aqueous solubility. ## Aim and Methods To improve solubility and further increase therapeutic efficacy, we prepared LA67-loaded polymeric micelles (LA67-PMs) using a film hydration method. The physicochemical properties of LA67-PMs were investigated, and the antitumor activity of this formulation against Colon26 (C26) cancer cell line was evaluated in vitro and in vivo with LA67 as a control. ## Results Polymeric micelles containing LA67 had a particle size of 17.88 nm and a drug entrapment efficiency of 94.84%. This formulation dispersed completely in aqueous solution and exhibited slow, sustained release of LA67. Cellular uptake assay showed that LA67-PMs delivered LA67 to cancer cells with greater efficiency than free LA67, which resulted in increased LA67 accumulation in cancer cells. Cell counting kit 8 (CCK-8) assay showed that blank polymeric micelles (PMs) exhibited low toxicity and LA67-PMs exerted pronounced anti-proliferation effects against C26 cells. Furthermore, LA67-PMs induced apoptosis and repr

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Author

Minhu Cui; Mingji Jin; Mingfeng Han; Yingda Zang; Chuangjun Li; Dongming Zhang; Wei Huang; Zhonggao Gao; Xuezhe Yin

Publisher

Informa UK Limited

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)