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Influence of Surgery and Endotoxin-induced Sepsis Combined on Natural Killer Cell Activity, Oxidative Burst of Granulocytes and Antigen Presentation Capability of Monocytes by P. Toft; Dagnæs-Hansen; E. Tønnesen; M. S. Petersen is a Medicine article available to read on EtoBox.

What is Influence of Surgery and Endotoxin-induced Sepsis Combined on Natural Killer Cell Activity, Oxidative Burst of Granulocytes and Antigen Presentation Capability of Monocytes about?

**Background:** Cell mediated immunity is affected in the course of sepsis and following surgical stress. The natural killer (NK) cells, the granulocytes and the monocytes constitute the immediate unspecific cell mediated immunity. We therefore investigated the effect of surgery‐ and endotoxin‐induced sepsis on NK cells, granulocytes and monocytes in a two‐hit model. **Methods:** Three groups of 40 mice. Each group was divided into four groups of 10 mice. All the animals were anesthetized and subjected to either: laparotomy; treatment with __Escherichia coli__ endotoxin i.p.; laparotomy followed 20 min later by endotoxin i.p.; or left untreated as a control group. In the first 40 mice the NK cell activity in the spleen and number of NK cells in the liver were measured, in the second the oxidative burst of granulocytes, and in the third the antigen presentation capacity of monocytes. **Results:** Endotoxin stimulated the NK cell activity and up‐regulated the antigen presentation capability on monocytes. In contrast, surgical stress reduced the NK cell activity, the number of NK cells and down‐regulated the antigen presentation capability on monocytes. After surgery, followed by admi

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Author

P. Toft; Dagnæs-Hansen; E. Tønnesen; M. S. Petersen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-5172)

Published

2002

Language

EN

Field

Medicine (Health Sciences)