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Can I read A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine on EtoBox?
A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine by Cindy Hörner; Christoph Schürmann; Arne Auste; Aileen Ebenig; Samada Muraleedharan; Kenneth H. Dinnon; Tatjana Scholz; Maike Herrmann; Barbara S. Schnierle; Ralph S. Baric; Michael D. Mühlebach is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine about?
The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has spread worldwide, with millions of cases and more than 1 million deaths to date. The gravity of the situation mandates accelerated efforts to identify safe and effective vaccines. Here, we generated measles virus (MeV)-based vaccine candidates expressing the SARS-CoV-2 spike glycoprotein (S). Insertion of the full-length S protein gene in two different MeV genomic positions resulted in modulated S protein expression. The variant with lower S protein expression levels was genetically stable and induced high levels of effective Th1-biased antibody and T cell responses in mice after two immunizations. In addition to neutralizing IgG antibody responses in a protective range, multifunctional CD8 and CD4 T cell responses with S protein-specific killing activity were detected. Upon challenge using a mouse-adapted SARS-CoV-2, virus loads in vaccinated mice were significantly lower, while vaccinated Syrian hamsters revealed protection in a harsh challenge setup using an early-passage human patient isolate. These results are highly encouraging and support further development of MeV-based C
Who reads A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Cindy Hörner; Christoph Schürmann; Arne Auste; Aileen Ebenig; Samada Muraleedharan; Kenneth H. Dinnon; Tatjana Scholz; Maike Herrmann; Barbara S. Schnierle; Ralph S. Baric; Michael D. Mühlebach
- Publisher
- National Academy of Sciences; Proceedings of the National Academy of Sciences; Oxford University Press (OUP); Publons; ScienceOpen (ISSN 0027-8424)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)