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Differential Patterns of Allelic Loss in Estrogen Receptor‐positive Infiltrating Lobular and Ductal Breast Cancer by L. W. M. Loo; C. Ton; Y.‐W. Wang; D. I. Grove; H. Bouzek; N. Vartanian; M.‐G. Lin; X. Yuan; T. L. Lawton; J. R. Daling; K. E. Malone; C. I. Li; L. Hsu; P. L. Porter is a Medicine article available to read on EtoBox.
What is Differential Patterns of Allelic Loss in Estrogen Receptor‐positive Infiltrating Lobular and Ductal Breast Cancer about?
## Abstract The two main histological types of infiltrating breast cancer, lobular (ILC) and the more common ductal (IDC) carcinoma are morphologically and clinically distinct. To assess the molecular alterations associated with these breast cancer subtypes, we conducted a whole‐genome study of 166 archival estrogen receptor (ER)‐positive tumors (89 IDC and 77 ILC) using the Affymetrix GeneChip® Mapping 10K Array to identify sites of loss of heterozygosity (LOH) that either distinguished, or were shared by, the two phenotypes. We found single nucleotide polymorphisms (SNPs) of high‐frequency LOH (>50%) common to both ILC and IDC tumors predominately in 11q, 16q, and 17p. Overall, IDC had a slightly higher frequency of LOH events across the genome than ILC (fractional allelic loss = 0.186 and 0.156). By comparing the average frequency of LOH by chromosomal arm, we found IDC tumors with significantly (__P__ 25% informativity), we identified 78 and 466 individual SNPs with a higher frequency of LOH (__P__ < 0.05) in ILC and IDC tumors, respectively. Hierarchical clustering of these 544 SNPs grouped tumors into four major groups based on their patterns of LOH and retention of heterozy
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- Author
- L. W. M. Loo; C. Ton; Y.‐W. Wang; D. I. Grove; H. Bouzek; N. Vartanian; M.‐G. Lin; X. Yuan; T. L. Lawton; J. R. Daling; K. E. Malone; C. I. Li; L. Hsu; P. L. Porter
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Life Sciences)