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Risk-reducing effect of education in Alzheimer's disease by Sigrid Botne Sando; Stacey Melquist; Ashley Cannon; Michael Hutton; Olav Sletvold; Ingvild Saltvedt; Linda R. White; Stian Lydersen; Jan Aasly is a Medicine article available to read on EtoBox.

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## Abstract ## Objective To estimate the effect of education on the risk of Alzheimer's disease (AD). ## Methods 373 patients diagnosed with AD and 559 healthy control individuals without first degree relatives with known dementia, were included in a case‐control study (2003–2006). All individuals were genotyped for __APOE__ alleles. Odds ratio (OR) for developing AD was calculated by binary logistic regression, with the number of __APOE__ ε4 alleles and educational level as covariates. Analyses were carried out separately for men and women and for different age groups. ## Results Carriers of one __APOE__ ε4 allele had OR of 4.2, and carriers of two __APOE__ ε4 alleles OR of 12.4 for developing AD. When adjusted for the number of __APOE__ ε4 alleles, OR for developing AD was significantly reduced in participants with 8–9 years of education compared to those with only 6–7 years, and was reduced further for those with 10–18 years of education. These findings were obtained for all the age groups studied and for both men and women. ## Conclusions Education had a consistently protective effect on the risk of developing clinical AD in a dose‐dependent manner in both men and women, and in

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Author

Sigrid Botne Sando; Stacey Melquist; Ashley Cannon; Michael Hutton; Olav Sletvold; Ingvild Saltvedt; Linda R. White; Stian Lydersen; Jan Aasly

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0885-6230)

Published

2008

Language

EN

Field

Medicine (Health Sciences)