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Can I read Naturally occurring antibodies to cholesterol: a new theory of LDL cholesterol metabolism on EtoBox?
Naturally occurring antibodies to cholesterol: a new theory of LDL cholesterol metabolism by Carl R. Alving; Nabila M. Wassef is a Immunology and Microbiology article available to read on EtoBox.
What is Naturally occurring antibodies to cholesterol: a new theory of LDL cholesterol metabolism about?
hirteen Nobel prizes awarded for research on the structure, conformation, synthesis and receptor cell biology of cholesterol and related molecules has prompted the comment that 'cholesterol is the most highly decorated small molecule in biology' 1 . The discovery of the low-density lipoprotein (LDL) receptor-mediated pathway for cholesterol homeostasis by Brown and Goldstein has led to an armamentarium of successful drugs and drug strategies aimed at lowering LDL, very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) cholesterol levels by inhibiting cholesterol biosynthesis and upregulating LDL receptor expression [1][2][3][4] . An ambitious goal has now been set for the elimination of coronary disease early in the next century 5 . Despite the panoply of cholesterol-lowering drugs, the achievement of this goal is a challenge that could still benefit from further theoretical and therapeutic insights 6,7 . Could immunological mechanisms play a role in cholesterol metabolism? In this article we propose that a specific immunological mechanism, opsonization of LDL, VLDL and IDL cholesterol by the binding of naturally occurring antibodies to cholesterol, results
Who reads Naturally occurring antibodies to cholesterol: a new theory of LDL cholesterol metabolism?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Carl R. Alving; Nabila M. Wassef
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0167-5699)
- Published
- 1999
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)