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High-grade Prostate Intraepithelial Neoplasia Shares Cytogenetic Alterations with Invasive Prostate Cancer by Antonio Alcaraz; Miguel A. Barranco; Juan M. Corral; Maria J. Ribal; Ana Carrió; Carme Mallofré; Juan Llopis; Alfredo Cetina; Ricardo Alvarez-Vijande is a Medicine article available to read on EtoBox.
What is High-grade Prostate Intraepithelial Neoplasia Shares Cytogenetic Alterations with Invasive Prostate Cancer about?
## Abstract ## BACKGROUND High‐grade prostate intraepithelial neoplasia (PIN) is the most likely precursor of prostate adenocarcinoma. However, the relationship between this lesion and prostate cancer has not yet been established. The detection of cytogenetic changes in the lesions prior to prostate adenocarcinoma would be useful in demonstrating such a pathogenic relationship. ## METHODS Twenty eight high‐grade PIN cases were found among 57 specimens of radical prostatectomy performed for clinically localized prostate cancer. Fluorescence in situ hybridization (FISH) analysis using centromeric probes to enumerate chromosomes 7, 8, 10, and 12 was performed to study the numerical chromosome alterations. FISH analysis was carried out over isolated nuclei obtained from high‐grade PIN areas and prostate cancer foci in the same prostatectomy specimen. ## RESULTS Of the 28 suitable cases it was possible to complete the study in 26 tumor and 20 PIN areas. The remaining cases were excluded because of insufficient tissue or poor preservation. Cytogenetic alterations (aneuploidy) were found in 16 of the 26 (62%) tumors studied. The most frequent chromosome alteration was trisomy 7, detected
Who reads High-grade Prostate Intraepithelial Neoplasia Shares Cytogenetic Alterations with Invasive Prostate Cancer?
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- Author
- Antonio Alcaraz; Miguel A. Barranco; Juan M. Corral; Maria J. Ribal; Ana Carrió; Carme Mallofré; Juan Llopis; Alfredo Cetina; Ricardo Alvarez-Vijande
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)