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Disorders of Sexual Development: Current Status and Progress in the Diagnostic Approach by Mary García-Acero; Olga Moreno; Fernando Suárez; Adriana Rojas is a Medicine article available to read on EtoBox.

What is Disorders of Sexual Development: Current Status and Progress in the Diagnostic Approach about?

Disorders of sexual development (DSD) are conditions with an atypical chromosomal, gonadal or phenotypic sex, which leads to differences in the development of the urogenital tract and different clinical phenotypes. Some genes have been implicated in the sex development during gonadal and functional differentiation where the maintenance of the somatic sex of the gonad as either male or female is achieved by suppression of the alternate route. The diagnosis of DSD requires a structured approach, involving a multidisciplinary team and different molecular techniques. We discuss the dimorphic genes and the specific pathways involved in gonadal differentiation, as well as new techniques for genetic analysis and their diagnostic value including epigenetic mechanisms, expanding the evidence in the diagnostic approach of individuals with DSD to increase knowledge of the etiology.

Who reads Disorders of Sexual Development: Current Status and Progress in the Diagnostic Approach?

Author

Mary García-Acero; Olga Moreno; Fernando Suárez; Adriana Rojas

Published

2020

Language

EN

Field

Medicine (Health Sciences)