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Promoter-mediated Diversification of Transcriptional Bursting Dynamics Following Gene Duplication by Edward Tunnacliffe; Adam M. Corrigan; Jonathan R. Chubb is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Promoter-mediated Diversification of Transcriptional Bursting Dynamics Following Gene Duplication about?

Significance Gene transcription occurs in discontinuous bursts. Although bursts are conserved in all forms of life, the causes and implications of bursting are not clear. Here we delineate a specific cause of bursts and contextualize the significance of bursting, using analysis of a gene family encoding 17 identical actin proteins. Although the genes show similar developmental expression, which is coupled in single cells, they show strong differences in bursting dynamics. These distinct bursting patterns indicate that different signals regulate the individual genes and suggest expansion of the family may have allowed diversification of actin gene regulation. By exchanging the promoters of genes, we show that the dominant driver of bursting dynamics is the gene promoter, not the genome context.

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Author

Edward Tunnacliffe; Adam M. Corrigan; Jonathan R. Chubb

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)