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Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation by Guiqin Bai; Yiqi Qiao; Po-Chieh Lo; Lei Song; Yuna Yang; Lining Duan; Sufen Wei; Min Li; Shuiqing Huang; Beiping Zhang; Qi Wang; Cong Yang is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation about?
## Ethnopharmacological relevance: Jiao-tai-wan (jtw) is a very famous traditional chinese medicine formula for the treatment of psychiatric disorders, especially in anxiety, insomnia and depression. however, its molecular mechanism of treatment remains indistinct. ## Aim of the study: We aimed to reveal the action mechanism of jtw on anti-depression via inhibiting microglia activation and pro-inflammatory response both in vivo and in vitro. ## Material and methods: The corticosterone (cort)-induced depression mouse model was used to evaluate the therapeutic efficacy of jtw. behavioral tests (open field, elevated plus maze, tail suspension and forced swim test) were conducted to evaluate the effect of jtw on depressive-like behaviors. the levels of inflammatory factors and the concentration of neurotransmitters were detected by rt-qpcr or elisa assays. then three hippocampal tissue samples per group (control, cort, and jtw group) were sent for rna sequencing (rna-seq). transcriptomics data analysis was used to screen the key potential therapeutic targets and signaling pathways of jtw. based on 8 bioactive species of jtw by our previous study using high-performance liquid chromatogr
Who reads Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Guiqin Bai; Yiqi Qiao; Po-Chieh Lo; Lei Song; Yuna Yang; Lining Duan; Sufen Wei; Min Li; Shuiqing Huang; Beiping Zhang; Qi Wang; Cong Yang
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)