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A Systematic Review of the Prognostic Value of Motor Abnormalities on Clinical Outcome in Psychosis by Lydia E. Pieters; Niluja Nadesalingam; Sebastian Walther; Peter N. van Harten is a Neuroscience article available to read on EtoBox.

What is A Systematic Review of the Prognostic Value of Motor Abnormalities on Clinical Outcome in Psychosis about?

Schizophrenia spectrum disorders have heterogeneous outcomes and currently no marker predicts the course of illness. Motor abnormalities (MAs) are inherent to psychosis, the risk of psychosis, symptom severity, and brain alterations. However, the prognostic value of MAs is still unresolved. Here, we provide a systematic review of longitudinal studies on the prognostic role of MAs spanning individuals at clinical high risk for psychosis (CHR), patients with first-episode psychosis (FEP), and chronic schizophrenia. We included 68 studies for a total of 23,630 subjects that assessed neurological soft signs (NSS), hypo- or hyperkinetic movement disorders and/or catatonia as a prognostic factor on clinical and functional outcomes. We found increased levels of MAs, in particular NSS, parkinsonism, and dyskinesia, were related to deteriorating symptomatic and poor functional outcome over time. Collectively, the findings emphasize the clinical, prognostic and scientific relevance of MA assessment and detection in individuals with or at risk of psychosis. In the future, instrumental measures of MA are expected to further augment detection, early intervention and treatment strategies in psyc

Who reads A Systematic Review of the Prognostic Value of Motor Abnormalities on Clinical Outcome in Psychosis?

Author

Lydia E. Pieters; Niluja Nadesalingam; Sebastian Walther; Peter N. van Harten

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)