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MUC1 peptide epitopes associated with five different H‐2 class I molecules by Vasso Apostolopoulos; John S. Haurum; Ian F. C. McKenzie is a Immunology and Microbiology article available to read on EtoBox.

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## MUCl peptide epitopes associated with five different H-2 class I molecules We have previously described the induction of murine CD8' major histocompatibility complex (MHC) class I-restricted cytotoxic T cells (CTL) recognizing the 20-amino acid repeat region of the human mucin 1 (MUC1) variable number of tandem repeats region (VNTR), a mucin greatly increased in expression in breast cancer and proposed as a target for immunotherapy. In that study, CTL could detect MUCl peptides associated with the MHC of all nine strains examined, and we now report the different epitopes presented by five different MHC class I molecules. The epitopes were defined in CTL assays using peptidepulsed phytohemagglutinin blasts or MHC class I-transfected L cells as targets; in addition, peptide binding assays and T cell proliferation studies were performed. Within the 20-amino acid VNTR, nine potential epitopes could be defined. The epitopes for the four MHC class I molecules [Kb (three epitopes), Dd, Ld and Kk] were closely related, all containing the amino acids PDTRPAP. For Db, three epitopes were identified, all containing APGSTAP. Most of the epitopes did not contain a consensus motif for the par

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Author

Vasso Apostolopoulos; John S. Haurum; Ian F. C. McKenzie

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)