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Amorphous Calcium Phosphates: Solvent‐Controlled Growth and Stabilization through the Epoxide Route by Paula Borovik; Víctor Oestreicher; Cristián Huck‐Iriart; Matías Jobbágy is a Chemistry article available to read on EtoBox.

What is Amorphous Calcium Phosphates: Solvent‐Controlled Growth and Stabilization through the Epoxide Route about?

## Abstract Calcium phosphates stand among the most promising nanobiomaterials in key biomedical applications, such as bone repairment, signalling or drug/gene delivery. Their intrinsic properties as crystalline structure, composition, particle shape and size define their successful use. Among these compounds, metastable amorphous calcium phosphate (ACP) is currently gaining particular attention due to its inherently high reactivity in solution, which is crucial in bone development mechanisms. However, the preparation of this highly desired (bio)material with control over its shape, size and phase purity remains as a synthetic challenge. In this work, the epoxide route was adapted for the synthesis of pure and stable ACP colloids. By using biocompatible solvents, such as ethylene glycol and/or glycerine, it was possible to avoid the natural tendency of ACP to maturate into more stable and crystalline apatites. Moreover, this procedure offers size control, ranging from small nanoparticles (60 nm) to micrometric spheroids (>500 nm). The eventual fractalization of the internal mesostructured can be tuned, by simply adjusting the composition of the ethylene glycol:glycerine solvent mix

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Author

Paula Borovik; Víctor Oestreicher; Cristián Huck‐Iriart; Matías Jobbágy

Publisher

Wiley

Published

2021

Language

EN

Field

Chemistry (Physical Sciences)