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Can I read Downregulation of Osteopontin Contributes to Metastasis Suppression by Breast Cancer Metastasis Suppressor 1 on EtoBox?
Downregulation of Osteopontin Contributes to Metastasis Suppression by Breast Cancer Metastasis Suppressor 1 by Benjamin D. Hedley; Danny R. Welch; Alison L. Allan; Waleed Al-Katib; David W. Dales; Carl O. Postenka; Graham Casey; Ian C. MacDonald; Ann F. Chambers is a Medicine article available to read on EtoBox.
What is Downregulation of Osteopontin Contributes to Metastasis Suppression by Breast Cancer Metastasis Suppressor 1 about?
## Abstract Breast cancer metastasis suppressor 1 (BRMS1) inhibits the ability of multiple human and murine cancer cell lines to metastasize to lymph nodes, bones and lungs. Comparison of mRNA expression in metastatic MDA‐MB‐435 human carcinoma cells (435) and metastasis‐suppressed BRMS1 transfectants (435/BRMS1) showed a marked (>90%) reduction of osteopontin (OPN) mRNA and protein expression in BRMS1‐overexpressing cells. OPN expression is associated with disease progression in patients, with higher levels of OPN produced by cancer cells associated with poorer patient survival. Furthermore, OPN has been suggested to promote survival of cancer cells in response to stress, although the mechanisms by which this may occur remain poorly understood. This study tested the hypothesis that re‐expression of OPN in metastasis‐suppressed 435/BRMS1 cells would reverse metastasis suppression and confer protection from stress‐induced apoptosis. A stable pooled population of OPN overexpressing 435/BRMS1 cells was created (435/BRMS1/OPN). OPN re‐expression did not affect __in vitro__ cell growth rates; however, increased anchorage independent growth/survival and protection from hypoxia‐induced ap
Who reads Downregulation of Osteopontin Contributes to Metastasis Suppression by Breast Cancer Metastasis Suppressor 1?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Benjamin D. Hedley; Danny R. Welch; Alison L. Allan; Waleed Al-Katib; David W. Dales; Carl O. Postenka; Graham Casey; Ian C. MacDonald; Ann F. Chambers
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)