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“Fight-flight-or-freeze” – how Yarrowia lipolytica responds to stress at molecular level? by Ewelina Celińska is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract __Yarrowia lipolytica__ is a popular yeast species employed in multiple biotechnological production processes. High resistance to extreme environmental conditions or metabolic burden triggered by synthetically forced over-synthesis of a target metabolite has its practical consequences. The proud status of an “industrial workhorse” that __Y. lipolytica__ has gained is directly related to such a quality of this species. With the increasing amount of knowledge coming from detailed functional studies and comprehensive omics analyses, it is now possible to start painting the landscape of the molecular background behind stress response and adaptation in __Y. lipolytica__. This review summarizes the current state-of-art of a global effort in revealing how __Y. lipolytica__ responds to both environmental threats and the intrinsic burden caused by the overproduction of recombinant secretory proteins at the molecular level. Detailed lists of genes, proteins, molecules, and biological processes deregulated upon exposure to external stress factors or affected by over-synthesis of heterologous proteins are provided. Specificities and universalities of __Y. lipolytica__ cellular resp

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Author

Ewelina Celińska

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)