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Simplified ^13^C metabolic modeling for simplified measurements of cerebral TCA cycle rate in vivo by Julien Valette; Fawzi Boumezbeur; Philippe Hantraye; Vincent Lebon is a Medicine article available to read on EtoBox.

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## Abstract ^13^C NMR spectroscopy is a unique tool to measure the cerebral tricarboxylic acid (TCA) cycle rate in vivo. The measurement relies on metabolic modeling of glutamate C3 and C4 enrichment time courses during a ^13^C‐glucose intravenous infusion. Usual metabolic models require the plasma glucose and ^13^C‐glucose time courses as input functions, as well as the knowledge of Michaelis‐Menten kinetics parameters governing passage through the blood‐brain barrier. It is shown in the present work that, when using an infusion protocol yielding a rapidly stable plasma glucose fractional enrichment, metabolic modeling can be simplified in such a manner that this additional information on input function and glucose transport is no longer required, significantly simplifying the measurement of cerebral TCA cycle rate in vivo. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.

Who reads Simplified ^13^C metabolic modeling for simplified measurements of cerebral TCA cycle rate in vivo?

Author

Julien Valette; Fawzi Boumezbeur; Philippe Hantraye; Vincent Lebon

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2009

Language

EN

Field

Medicine (Health Sciences)