Can I read Improved Serotonergic Neurotransmission by Genistein Pretreatment Regulates Symptoms of Obsessive-compulsive Disorder in Streptozotocin-induced Diabetic Mice on EtoBox?

Improved Serotonergic Neurotransmission by Genistein Pretreatment Regulates Symptoms of Obsessive-compulsive Disorder in Streptozotocin-induced Diabetic Mice by Pradeep Phadnis; Purnima Dey Sarkar; Mithun Singh Rajput is a Medicine article available to read on EtoBox.

What is Improved Serotonergic Neurotransmission by Genistein Pretreatment Regulates Symptoms of Obsessive-compulsive Disorder in Streptozotocin-induced Diabetic Mice about?

## Abstract ## Background Initial evidences have shown that diabetes mellitus occurs concomitantly with obsessive-compulsive disorder (OCD) symptomatology. Serotonergic psychiatric therapy posits that serotonin is a central character in the management of OCD. Hence, it is worth investigating novel chemical entities affecting the serotonergic system for targeting OCD. An isoflavonoid phytoestrogen, genistein, has been recognized as of great pharmacological value especially for protecting neurodegeneration, depression (serotonin regulation), and diabetes. The effectiveness of genistein pretreatment on the symptoms of OCD in streptozotocin-induced diabetic mice is investigated in this study. We also evaluate the probable involvement of the serotonergic system. ## Methods Groups of diabetic mice were treated with genistein at the dose of 5.0 and 10.0 mg/kg (intraperitoneal, twice daily, 14 days), and symptoms of OCD were assessed by the marble-burying behavior, in comparison with the standard drug fluoxetine. Neurochemical assessment of the serotonergic ratio 5-hydroxyindole-3-methoxyphenylacetic acid/5-hydroxytryptamine (5-HIAA/5-HT) in the cortical region of the brain was performed u

Who reads Improved Serotonergic Neurotransmission by Genistein Pretreatment Regulates Symptoms of Obsessive-compulsive Disorder in Streptozotocin-induced Diabetic Mice?

Author

Pradeep Phadnis; Purnima Dey Sarkar; Mithun Singh Rajput

Publisher

Walter de Gruyter GmbH

Published

2018

Language

EN

Field

Medicine (Life Sciences)