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Contributions of Cardiac Dysfunction and Volume Status to Central Haemodynamics in Chronic Heart Failure by Wayne L. Miller; Hidemi Sorimachi; Diane E. Grill; Karen Fischer; Barry A. Borlaug is a Medicine article available to read on EtoBox.

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## Abstract ## Aims Elevated cardiac filling pressures producing clinical congestion in heart failure (HF) patients may be secondary to intravascular volume expansion or abnormalities in cardiac diastolic properties. The objective of this study was to assess the extent to which measures of myocardial function and intravascular volume correlate with haemodynamic abnormalities in chronic HF. ## Methods and results Subjects underwent invasive haemodynamic assessment, measurement of total blood volume (TBV) using radiolabel indicator‐dilution methodology, and echocardiography to evaluate cardiac structure and function. Patients were divided into those with hypervolaemia (defined as TBV > +8% above referenced normal volume) and normal volume (‘euvolaemia’) (TBV ≤ + 8%). Of 66 patients, 39 (59%) were hypervolaemic and 27 (41%) normal TBV. Central venous pressure (CVP, P = 0.01) and pulmonary capillary wedge pressure (PCWP, P < 0.001) were higher in hypervolaemic compared with euvolaemic patients; however, 15% of hypervolaemic patients displayed normal pressures. Of euvolaemic patients, 70% displayed elevated CVP and 63% elevated PCWP. PCWP was moderately correlated with TBV (r = 0.42), l

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Author

Wayne L. Miller; Hidemi Sorimachi; Diane E. Grill; Karen Fischer; Barry A. Borlaug

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)