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Concomitant Weekly Cisplatin and Altered Fractionation Radiotherapy in Locally Advanced Head and Neck Cancer by Heather E. Newlin; Robert J. Amdur; Charles E. Riggs; Christopher G. Morris; Jessica M. Kirwan; William M. Mendenhall is a Medicine article available to read on EtoBox.

What is Concomitant Weekly Cisplatin and Altered Fractionation Radiotherapy in Locally Advanced Head and Neck Cancer about?

## Abstract ## BACKGROUND: Both concomitant chemotherapy and altered fractionation radiotherapy (RT) have been shown to improve outcomes for patients with locoregionally advanced head and neck squamous cell carcinomas. However, both strategies also increase acute toxicity, and it is questionable whether the 2 can be safely combined. Traditional concomitant chemotherapy regimens include high‐dose cisplatin given at 100 mg/m^2^ every 3 weeks. The authors' purpose was to report efficacy and toxicity after weekly cisplatin (30 mg/m^2^/wk) concurrent with altered fractionation RT. ## METHODS: One hundred twenty‐one patients with American Joint Committee on Cancer stages II (3%), III (13%), or IV (84%) squamous cell carcinomas of the oropharynx (70%), hypopharynx (20%), or larynx (10%) were treated between 2000 and 2006 at the University of Florida with hyperfractionated RT (55 patients) or concomitant boost RT (66 patients) and concomitant cisplatin (30 mg/m^2^/wk). ## RESULTS: Median follow‐up was 2.9 years; median follow‐up on survivors was 3.6 years. Seventy‐nine percent of patients completed ≥6 cycles of chemotherapy; 94% received ≥7200 centigrays. Seven (6%) patients changed from c

Who reads Concomitant Weekly Cisplatin and Altered Fractionation Radiotherapy in Locally Advanced Head and Neck Cancer?

Author

Heather E. Newlin; Robert J. Amdur; Charles E. Riggs; Christopher G. Morris; Jessica M. Kirwan; William M. Mendenhall

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2010

Language

EN

Field

Medicine (Health Sciences)