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Treatment of tremor in Parkinson's disease by subthalamic nucleus stimulation by P. Krack; Abdelhamid Benazzouz; Pierre Pollak; Patricia Limousin; Brigitte Piallat; Dominique Hoffmann; Jing Xie; Alim‐Louis Benabid is a Medicine article available to read on EtoBox.
What is Treatment of tremor in Parkinson's disease by subthalamic nucleus stimulation about?
## Abstract The recent resurgent interest in functional surgery for the treatment of Parkinson's disease (PD) has focused on the effects on akinesia and levodopa‐induced dyskinesia. Stimulation of the subthalamic nucleus (STN) improves akinesia and rigidity but its effects on tremor have not been studied. The objective of this study was to assess the efficacy of STN stimulation on tremor in patients with the complete parkinsonian triad with motor fluctuations. Of 27 consecutive patients with STN stimulation (26 bilateral), 15 exhibited tremor rated at least 2/4 according to item 20 (rest tremor) of the Unified Parkinson's Disease Rating Scale (UPDRS) in at least one limb. The mean preoperative tremor score was 11.3 ± 5.6 in off‐drug and 1.2 ± 2.4 in on‐drug conditions. The postoperative tremor scores at the last follow up (from 1–12 months) were 2.2 ± 2.2 off‐drug/on‐stimulation and 0.2 ± 0.4 on‐drug/on‐stimulation. Both rest and action tremors were improved in all patients. The UPDRS tremor score was reduced by 80%, rigidity score by 65%, and akinesia score by 51% on average. For the three symptoms, the stimulation effect was close to that induced before surgery by a suprathreshol
Who reads Treatment of tremor in Parkinson's disease by subthalamic nucleus stimulation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- P. Krack; Abdelhamid Benazzouz; Pierre Pollak; Patricia Limousin; Brigitte Piallat; Dominique Hoffmann; Jing Xie; Alim‐Louis Benabid
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)