About this Medicine article
Topical Cyclosporine in Thyroid Orbitopathy-Related Dry Eye: Clinical Findings, Conjunctival Epithelial Apoptosis, and MMP-9 Expression by Canan Gürdal; İpek Genç; Özge Saraç; İpek Gönül; Tamer Takmaz; İzzet Can is a Medicine article available to read on EtoBox.
## Objectives: To evaluate the effects of topical cyclosporine a (csa) 0.05% (restasis) on the signs and symptoms of dry eye, on apoptosis, and on mmp-9 expression in conjunctiva epithelial cells in thyroid orbitopathy (to)-related dry eye patients. ## Methods: Prospective, clinical study. twenty-four eyes of 12 consecutive to patients with dry eye findings instilled csa twice daily for 2 months. ocular surface disease index, schirmer tear test, tear breakup time (tbut), conjunctival apoptosis index, and conjunctival mmp-9 expression were evaluated before and after 2 months treatment. conjunctival biopsies were harvested from all eyes at baseline and after 2 months treatment. apoptosis was detected by the terminal deoxynucleotidyl transferase-mediated dutp-nick end labeling (tunel) assay. mmp-9 expression was determined by immunohistochemistry. ## Results: After 2 months of topical csa treatment, the mean osdi score was significantly decreased from 58.08 +/- 6.28 to 36.41 +/- 11.75 (p = 0.001). at baseline, the mean schirmer tear test score was 8.92 +/- 5.52 mm. it was increased to 11.25 +/- 4.71 mm after treatment (p > 0.05). the mean tbut increased significantly from 3.92 +/- 2.1
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- Author
- Canan Gürdal; İpek Genç; Özge Saraç; İpek Gönül; Tamer Takmaz; İzzet Can
- Publisher
- Informa UK Limited
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)