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Effects of Luteolin and Luteolin-morphine Co-administration on Acute and Chronic Pain and Sciatic Nerve Ligated-induced Neuropathy in Mice by Mahmoud Hashemzaei; Mina Abdollahzadeh; Mehrdad Iranshahi; Ebrahim Golmakani; Ramin Rezaee; Kaveh Tabrizian is a Medicine article available to read on EtoBox.

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## Abstract ## Background Neuropathic pain (NP) is a common condition accompanied by nerve injury. To date, there is no definite treatment approved for this disorder. In addition, many drugs that are used for NP cause adverse reactions. Luteolin is a naturally occurring flavonoid with diverse pharmacological properties such as anti-inflammatory, antioxidant and anticancer. We sought to investigate luteolin effects on chronic, acute and neuropathic pain as well as its potential to increase morphine anti-nociceptive effects in mice. ## Methods Albino mice (20–25 g) were randomly divided into 14 groups (n=7) including morphine 1 mg/kg body weight +luteolin (5 mg/kg body weight), morphine (9 mg/kg body weight, i.p.), luteolin (2.5, 5 and 10 mg/kg body weight), imipramine 40 mg/kg body weight and normal saline (NS) (0.9 %) as vehicle and subjected to hot plate test. Formalin test was done in the following groups: NS, diclofenac sodium (10 mg/kg body weight, i.p.), morphine (9 mg/kg body weight, i.p.) and luteolin (2.5, 5 and 10 mg/kg body weight). ## Results Administration of luteolin single dose (5 and 10 mg/kg body weight) significantly reduced neuropathic pain ( p < 0.05 $\rm{p}<0.05

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Author

Mahmoud Hashemzaei; Mina Abdollahzadeh; Mehrdad Iranshahi; Ebrahim Golmakani; Ramin Rezaee; Kaveh Tabrizian

Publisher

Walter de Gruyter GmbH

Published

2017

Language

EN

Field

Medicine (Health Sciences)