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Osteonecrosis Development in a Novel Rat Model Characterized by a Single Application of Oxidative Stress by Toru Ichiseki; Ayumi Kaneuji; Yoshimichi Ueda; Shintaro Nakagawa; Tomoaki Mikami; Kiyokazu Fukui; Tadami Matsumoto is a Medicine article available to read on EtoBox.
What is Osteonecrosis Development in a Novel Rat Model Characterized by a Single Application of Oxidative Stress about?
## Objective: To investigate the relationship between transient oxidative stress and the development of osteonecrosis in a rat model. ## Methods: A total of 160 male wistar rats (24 weeks old) were injected only once with the pro-oxidant dl-buthionine-(s,r)-sulfoximine (bso) (500 mg/kg given intraperitoneally) and were killed 12 hours (group a), 1 day (group b), 3 days (group c), 4 days (group d), 5 days (group e), 7 days (group f), or 14 days (group g) after administration (n = 20 per group). twenty untreated rats were used as a control group (group n). femurs were examined histopathologically for the presence of osteonecrosis, and reduced glutathione (gsh) in liver tissue was measured as an index of oxidative stress. ## Results: Gsh decreased rapidly after bso administration. significant decreases were noted in groups a and b as compared to group n (p < 0.0001 and p = 0.0007, respectively), confirming the development of transient extreme oxidative stress soon after bso administration. the histopathologic study revealed osteonecrosis in 10% of the rats in group e, 35% of the rats in group f, and 40% of the rats in group g. ## Conclusion: Transient extreme oxidative stress was conf
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- Author
- Toru Ichiseki; Ayumi Kaneuji; Yoshimichi Ueda; Shintaro Nakagawa; Tomoaki Mikami; Kiyokazu Fukui; Tadami Matsumoto
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)