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Blood and Alveolar Lymphocyte Subsets in Pulmonary Cytomegalovirus Infection After Lung Transplantation by François Stéphan; Jean-François Bernaudin; Danielle Cesari; Anne Fajac; Dominique MD Grenet; Isabelle Caubarrere; Marc Stern is a Medicine article available to read on EtoBox.

What is Blood and Alveolar Lymphocyte Subsets in Pulmonary Cytomegalovirus Infection After Lung Transplantation about?

## Background: Cytomegalovirus (cmv) pneumonitis has been shown to be associated with lymphocytic alveolitis after lung transplantation. in the present study, we investigated a series of bronchoalveolar (bal) and blood samples, collected in the absence of rejection or acute infectious episodes. in order -1: to evaluate intra-alveolar cell population changes concomitant with cmv replication and -2: to reappraise the value of cell population analysis in the management of patients after lung transplantation. ## Methods: We used flow cytometry to investigate modifications of lymphocyte subpopulations related to pulmonary cytomegalovirus infections in blood and bal samples from a series of 13 lung transplant recipients. after exclusion of samples obtained during pulmonary rejection, bronchiolitis obliterans or acute bacterial infection, 48 blood and bal samples were retained for analysis: 17 were cmv positive by shell-vial assay and 31 were cmv negative in blood and bal. ## Results: Our results demonstrate that pulmonary cmv infection is associated with a significant increase in the total lymphocyte population in bal samples, but with minor modifications of the various lymphocyte subpop

Who reads Blood and Alveolar Lymphocyte Subsets in Pulmonary Cytomegalovirus Infection After Lung Transplantation?

Author

François Stéphan; Jean-François Bernaudin; Danielle Cesari; Anne Fajac; Dominique MD Grenet; Isabelle Caubarrere; Marc Stern

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2334)

Published

2001

Language

EN

Field

Medicine (Health Sciences)