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Electron microscopy study of 496 cases of lupus nephritis: A single-center experience by Bahar Bagheri; Seyed Mohammad Owji; Simin Torabinezhad; Hadi Raeisi Shahraki; Amirhossein Kamalinia; Seyed Hossein Owji; Farshad Dehghani is a Medicine article available to read on EtoBox.

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Introduction: Renal involvement is seen in about 40-82% of systemic lupus erythematosus (SLE) Asian patients. The exact diagnosis and classification of lupus nephritis are important for treatment and prognosis. This study aimed to investigate the value of electron microscopy (EM) in the diagnosis and classification of lupus nephritis compared with light microscopy. Method: In this cross-sectional referral-center 16-year study of lupus nephritis, the final diagnosis was based on the EM study. Primary light microscopy findings were compared with EM diagnosis. Moreover, Immunofluorescence patterns distribution was assessed. Results: From 496 patients diagnosed with lupus nephritis based on EM, 225(45.4%) of patients were categorized in class IV, followed by 98(19.7%), 93(18.8%), 46(9.3%), and 14(2.8%) who were categorized into classes of II, III, V, and VI respectively. Only 1(0.2%) patient belonged to class I, and 19(3.8%) cases were diagnosed with mixed two classes. Using EM was essential for diagnosing 25.6% of cases taking the correct classification by light microscopy into account; however, disregarding correct classification, this could change to a 7.4% contribution rate of EM.

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Author

Bahar Bagheri; Seyed Mohammad Owji; Simin Torabinezhad; Hadi Raeisi Shahraki; Amirhossein Kamalinia; Seyed Hossein Owji; Farshad Dehghani

Publisher

SAGE Publications

Published

2021

Language

EN

Field

Medicine (Health Sciences)