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Transient expression of LIM‐domain transcription factors is coincident with delayed maturation of photoreceptors in the chicken retina by Andy J. Fischer; Shane Foster; Melissa A. Scott; Patrick Sherwood is a Neuroscience article available to read on EtoBox.

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## Abstract In the retina of warm‐blooded vertebrates, photoreceptors are specified many days before the onset of synaptogenesis and the expression of photopigments. The factors that regulate the maturation of photoreceptors in the developing retina remain unknown. We report here that photoreceptors transiently express LIM‐domain transcription factors during the development of the chicken retina. We examined the differentiation of photoreceptors through the normal course of embryonic development and at the far periphery of the postnatal retina, where the differentiation of photoreceptors is slowed and persists across a spatial gradient. In the embryonic retina, we find visinin‐positive photoreceptors that transiently express Islet2 and Lim3 starting at E8 and ending around E15, but persisting in far peripheral regions of the retina through the first 2 weeks of postnatal development. During early stages of photoreceptor maturation, there is coincident and transient expression of the LIM‐domain factors with axonin1, a cell surface glycoprotein that is a member of the immunoglobulin superfamily. Coincident with the downregulation of Islet2 and Lim3, we find the upregulation of calbind

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Author

Andy J. Fischer; Shane Foster; Melissa A. Scott; Patrick Sherwood

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

2007

Language

EN

Field

Neuroscience (Life Sciences)