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Can I read Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous leukaemia in the blastic phase on EtoBox?
Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous leukaemia in the blastic phase by Kensuke Kojima; Masaki Yasukawa; Fumihiko Ishimaru; Hiromichi Dansako; Yoshinobu Matsuo; Yukio Kimura; Yuichiro Nawa; Masamichi Hara; Mine Harada is a Medicine article available to read on EtoBox.
What is Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous leukaemia in the blastic phase about?
We report a case of Philadelphia‐positive chronic myelogenous leukaemia in blastic phase with the additional translocation (8;21)(q22;q22), which is frequent in acute myeloid leukaemia but not in chronic myelogenous leukaemia. The t(8;21) was not detected in the chronic phase, and was the only additional chromosomal anomaly in the blastic clone. Reverse transcription‐polymerase chain reaction revealed the AML1/ETO fusion transcript in the cells of blastic phase but not in those of chronic phase. Regarding t(9;22), the breakpoint on chromosome 22 occurred in the μ‐BCR region of the BCR gene, resulting in hybrid BCR/ABL mRNA with an e19a2 junction. Our findings provided molecular evidence that t(8;21) can occur as an additional genetic change in Philadelphia‐positive chronic myelogenous leukaemia.
Who reads Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous leukaemia in the blastic phase?
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- Author
- Kensuke Kojima; Masaki Yasukawa; Fumihiko Ishimaru; Hiromichi Dansako; Yoshinobu Matsuo; Yukio Kimura; Yuichiro Nawa; Masamichi Hara; Mine Harada
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)