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Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats by A.M.L. Coenen; W.H.I.M. Drinkenburg; M. Inoue; E.L.J.M. van Luijtelaar is a Medicine article available to read on EtoBox.

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In this review, the main characteristics of genetic models of absence epilepsy, in particular with respect to WAG/Rij rats, are presented. Genetic models are important and relevant, since evidence exists that these models mimic spontaneously occurring human epilepsy more than models in which epilepsy is artificially induced. Genetic models can be divided into models in which seizures are elicited and into those in which epilepsy appears without any sensory stimulation. The majority of genetic models show that absence type of epilepsy; during the last few years, we and others have noticed that rats of various strains exhibit spontaneously occurring spike-wave discharges in the EEG. Among the strains highly affected is the WAG/Rij strain, which is a fully inbred strain. Individuals are homozygous and because of this property, genetic studies are meaningful. Electrophysiological studies have indicated that abnormal discharges in the cortical EEG are generalized and that the hippocampus is not involved. Parts of the thalamus, together with the thalamic reticular nucleus, apparently act as a pacemaker for the abnormal discharges. There is a circadian modulation in the number of spike-wa

Who reads Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats?

Author

A.M.L. Coenen; W.H.I.M. Drinkenburg; M. Inoue; E.L.J.M. van Luijtelaar

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

1992

Language

EN

Field

Medicine (Health Sciences)