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CT-based liver surface nodularity for the detection of clinically significant portal hypertension: defining measurement quality criteria by Riccardo Sartoris; Marie Lazareth; Arianna Nivolli; Marco Dioguardi Burgio; Valérie Vilgrain; Maxime Ronot is a Medicine article available to read on EtoBox.
What is CT-based liver surface nodularity for the detection of clinically significant portal hypertension: defining measurement quality criteria about?
## Purpose: To establish measurement quality criteria for the noninvasive assessment of clinically significant portal hypertension (csph) in patients with cirrhosis using ct-based liver surface nodularity (lsn) measurements. ## Methods: Seventy-four consecutive patients with cirrhosis (mean 62 ± 13 years), including 30 with csph (41%), underwent ct and hepatic venous pressure gradient measurements. three independent readers performed 15 lsn measurements/patient using dedicated software. lsn was computed based on the median and means of one to 15 measurements. accuracy for diagnosing csph was assessed using receiver operating characteristic (roc) curve analysis. variability was assessed by the intra-class correlation coefficient (icc) and the bland-altman plot (ba). quality criteria were identified to maximize the accuracy of lsn and minimize variability. ## Results: The area under the (au) rocs of mean and median lsn measurements based on one to 15 measurements ranged from 0.79 ± 0.05 to 0.91 ± 0.04 and 0.86 ± 0.04 to 0.91 ± 0.03, respectively, with no difference on pair-wise comparisons (all p > 0.05). aurocs of lsn increased from one to eight and leveled off between eight and 15
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- Author
- Riccardo Sartoris; Marie Lazareth; Arianna Nivolli; Marco Dioguardi Burgio; Valérie Vilgrain; Maxime Ronot
- Publisher
- Springer-Verlag; Springer New York LLC; Springer Science and Business Media LLC (ISSN 2366-004X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)