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Changes in the Brain in Temporal Lobe Epilepsy with Unilat-eral Hippocampal Sclerosis: Initial Case Series by Seong Hoon Lim; Sung Chul Lim; Juhee Oh; Bo Young Hong is a Neuroscience article available to read on EtoBox.

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Temporal lobe epilepsy (TLE) is a network disorder of the brain; network disorders predomi-nately involve dysregulation of hippocampal function caused by neuronal hyperexcitability. However, the relationship between the macro-and microscopic changes in specific brain regions is uncertain. In this study, the pattern of brain atrophy in patients with TLE and hippocampal sclerosis (HS) was investigated using volumetry, and microscopic changes in specific lesions were observed to examine the anatomical correspondence with specific target lesions using dif-fusion tensor imaging (DTI) with statistical parametric mapping (SPM). This retrospective cross-sectional study enrolled 17 patients with TLE and HS. We manually measured the volumes of the hippocampus (HC), amygdala (AMG), entorhinal cortex, fornix, and thalamus (TH) bilat-erally. The mean diffusivity and fractional anisotropy of each patient were then quantified and analyzed by a voxel-based statistical correlation method using SPM8. In right TLE with HS, there was no evidence of any abnormal diffusion properties associated with the volume reduction in specific brain regions. In left TLE with HS, there were significant changes in th

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Author

Seong Hoon Lim; Sung Chul Lim; Juhee Oh; Bo Young Hong

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)