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Can I read Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions on EtoBox?
Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions by Sandra Fischer; Chiara Lichtenthaeler; Anastasiya Stepanenko; Florian Heyl; Daniel Maticzka; Katrin Kemmerer; Melina Klostermann; Rolf Backofen; Kathi Zarnack; Julia E. Weigand is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions about?
## Abstract HnRNPs are ubiquitously expressed RNA-binding proteins, tightly controlling posttranscriptional gene regulation. Consequently, hnRNP networks are essential for cellular homeostasis and their dysregulation is associated with cancer and other diseases. However, the physiological function of hnRNPs in non-cancerous cell systems are poorly understood. We analyzed the importance of HNRNPDL in endothelial cell functions. Knockdown of __HNRNPDL__ led to impaired proliferation, migration and sprouting of spheroids. Transcriptome analysis identified cyclin D1 (__CCND1__) and tropomyosin 4 (__TPM4__) as targets of HNRNPDL, reflecting the phenotypic changes after knockdown. Our findings underline the importance of HNRNPDL for the homeostasis of physiological processes in endothelial cells.
Who reads Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sandra Fischer; Chiara Lichtenthaeler; Anastasiya Stepanenko; Florian Heyl; Daniel Maticzka; Katrin Kemmerer; Melina Klostermann; Rolf Backofen; Kathi Zarnack; Julia E. Weigand
- Publisher
- Walter de Gruyter GmbH
- Published
- 2023
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)