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Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements by Hui Chen; Chenggang Lu; Brian Ouyang; Haili Zhang; Zhong Huang; Diksha Bhatia; Sung-Jin Lee; Darshini Shah; Asmiti Sura; Wen-Chen Yeh; Yang Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements about?
WNTs regulate myriad biological processes during embryonic development and are key regulators of stem cell function, tissue homeostasis, and injury repair in adults. The creation of WNT-based therapies has been hampered by challenges in developing soluble, potent, and selective WNT molecules. Soluble WNT surrogates have been reported, but they demonstrate relatively weak WNT signaling activity. Here, we describe a platform for potent, selective WNT surrogate generation. We identify multivalent binding to Frizzleds (FZDs) and low-density lipoprotein receptor-related proteins (LRPs) to be a requirement for maximal WNT/β-catenin activation. Furthermore, we show that recruitment of two different FZDs together with LRP causes efficient signaling. Surrogate WNT targeting either FZD or FZD induces expansive growth of intestinal organoids. This flexible WNT surrogate platform yields potent agonists with any desired receptor specificity and will be useful for research and therapeutic applications for tissue regeneration.
Who reads Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hui Chen; Chenggang Lu; Brian Ouyang; Haili Zhang; Zhong Huang; Diksha Bhatia; Sung-Jin Lee; Darshini Shah; Asmiti Sura; Wen-Chen Yeh; Yang Li
- Publisher
- Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 2451-9456)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)