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Axonal Injury and Peripheral Nerve Grafting in the Thalamus and Cerebellum of the Adult Rat: Upregulation of C-jun and Correlation with Regenerative Potential by E. Vaudano; G. Campbell; S. P. Hunt; A. R. Lieberman is a Neuroscience article available to read on EtoBox.

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## Abstract The protooncogene c‐__jun__ is highly expressed for long periods in axotomized PNS neurons. This may be related to their growth and regeneration. In contrast, axotomized CNS neurons show only a small and transient upregulation of c‐__jun__. It has been suggested that there may be a correlation between this failure to maintain high levels of c‐__jun__ expression after axotomy and abortive CNS axonal regeneration. We have studied, by __in situ__ hybridization and immunohistochemistry, the c‐__jun__ response after stab wound lesion, and after peripheral nerve grafting in the thalamus and cerebellum of the adult rat. A lesion elicits upregulation of c‐__jun__ in thalamic neurons ipsilateral to the lesion. This is most evident and prolonged in neurons such as those of the thalamic reticular nucleus, which have an established propensity to regenerate. After peripheral nerve grafting, the c‐__jun__ response in thalamic neurons is enhanced, mostly in neurons which have axons regenerating along the grafts. These neurons also upregulate growth‐associated protein 43 (__GAP‐43__). By comparison, injured Purkinje cells of the cerebellum which do not regenerate their axons along a gr

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Author

E. Vaudano; G. Campbell; S. P. Hunt; A. R. Lieberman

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

1998

Language

EN

Field

Neuroscience (Life Sciences)