Opening book details…
Can I read Distribution, characterization, and induction of CD8^+^ regulatory T cells and IL-17-producing CD8^+^ T cells in nasopharyngeal carcinoma on EtoBox?
Distribution, characterization, and induction of CD8^+^ regulatory T cells and IL-17-producing CD8^+^ T cells in nasopharyngeal carcinoma by Jiang Li; Zhou-Feng Huang; Geng Xiong; Hao-Yuan Mo; Fang Qiu; Hai-Qiang Mai; Qiu-Yan Chen; Jia He; Shu-peng Chen; Li-Min Zheng; Chao-Nan Qian; Yi-Xin Zeng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Distribution, characterization, and induction of CD8^+^ regulatory T cells and IL-17-producing CD8^+^ T cells in nasopharyngeal carcinoma about?
## Background CD8^+^ effector cells often have an antitumor function in patients with cancer. However, CD8^+^Foxp3^+^ regulatory T cells (Tcregs) and interleukin (IL)-17-producing CD8^+^ T cells (Tc17 cells) also derive from the CD8^+^ T cell lineage. Their role in the antitumor response remains largely unknown. In the present study, we aimed to investigate the distribution, characterization, and generation of CD8^+^ Tcregs and Tc17 cells in NPC patients. ## Methods Peripheral blood and tumor biopsy tissues from 21 newly diagnosed patients with nasopharyngeal carcinoma (NPC) were collected, along with peripheral blood from 21 healthy donors. The biological characteristics of Tcregs and Tc17 cells from blood and tumor tissues were examined by intracellular staining, tetramer staining and fluorescence-activated cell sorting (FACS) analysis. The suppressive function of Tcregs was investigated using a proliferation assay that involved co-culture of sorted CD8^+^CD25^+^ T cells with naïve CD4^+^ T cells __in vitro__. ## Results We observed an increased prevalence of Tcregs and Tc17 cells among tumor-infiltrating lymphocytes (TILs) and different distribution among peripheral blood mononu
Who reads Distribution, characterization, and induction of CD8^+^ regulatory T cells and IL-17-producing CD8^+^ T cells in nasopharyngeal carcinoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jiang Li; Zhou-Feng Huang; Geng Xiong; Hao-Yuan Mo; Fang Qiu; Hai-Qiang Mai; Qiu-Yan Chen; Jia He; Shu-peng Chen; Li-Min Zheng; Chao-Nan Qian; Yi-Xin Zeng
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2003-; Springer Science and Business Media LLC (ISSN 1479-5876)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)