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Synthesis of transition-state analogues as potential inhibitors of sialidase from Influenza virus by Pierre-Alexandre Driguez; Béatrice Barrere; Gérard Quash; Alain Doutheau is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Synthesis of transition-state analogues as potential inhibitors of sialidase from Influenza virus about?

Sodium 5-acetamido-2,6-anhydro-3,4,5-trideoxy-D-manno-non-2-enonate (2) has been synthesized from N-acetyl-4-deoxy-neuraminic acid methyl ester (4). Sodium 2,6-anhydro-3-deoxy-L-arabino-hept-2-enonate (3), 4-acetamido-2,6-anhydro-3,4-dideoxy-L-arabino-hept-2-enonic acid (18e), and 4-acetamido-2,6-anhydro-3,4-dideoxy-L-ribo-hept-2-enonic acid (18a) have been prepared from L-arabinose. The above compounds were investigated as inhibitors of sialidase from Influenza virus. Only compound 2 showed a significant inhibitory activity (Ki 8 x 10(-2) mM) against the enzyme.

Who reads Synthesis of transition-state analogues as potential inhibitors of sialidase from Influenza virus?

Author

Pierre-Alexandre Driguez; Béatrice Barrere; Gérard Quash; Alain Doutheau

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)

Published

1994

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)