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APE/Ref-1 and the mammalian response to genotoxic stress by Gerhard Fritz; Sabine Grösch; Maja Tomicic; Bernd Kaina is a Environmental Science article available to read on EtoBox.

What is APE/Ref-1 and the mammalian response to genotoxic stress about?

Human apurinic/apyrimidinic endonuclease/redox factor-1 (hAPE/Ref-1) is a multifunctional protein involved in the repair of DNA damaged by oxidative or alkylating compounds as well as in the regulation of stress inducible transcription factors such as AP-1, NF-B, HIF-1 and p53. With respect to transcriptional regulation, both redox dependent and independent mechanisms have been described. APE/Ref-1 also acts as a transcriptional repressor. Recent data indicate that APE/Ref-1 negatively regulates the activity of the Ras-related GTPase Rac1. How these different physiological activities of APE/Ref-1 are coordinated is poorly understood. So far, convincing evidence is available that the expression of the APE/Ref-1 gene is inducible by oxidative stress and that overexpressed APE/Ref-1 protein protects cells against the genotoxic and cell killing effects of reactive oxygen species (ROS), whereas down-regulation sensitizes cells. Therefore, APE/Ref-1 can be considered to be part of an adaptive cellular response mechanism to oxidative genotoxic stress. The physiological relevance of increase of either the repair or redox activity of APE/Ref-1 for this adaptive response is unclear. Data wil

Who reads APE/Ref-1 and the mammalian response to genotoxic stress?

Author

Gerhard Fritz; Sabine Grösch; Maja Tomicic; Bernd Kaina

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2003

Language

EN

Field

Environmental Science (Life Sciences)