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Her Nick 2006 by Apu kumar Das is a document available to read on EtoBox.
The study investigates the enzyme LpxC from Escherichia coli, which is crucial for lipid A biosynthesis and a target for antibiotic development against Gram-negative bacteria. It highlights the significant role of bound metal ions and fatty acids in the molecular recognition of ligands by LpxC, showing that the presence of the hydroxymyristoyl moiety greatly enhances binding affinity. The findings suggest that the effectiveness of LpxC inhibitors may be influenced by the metal ion status in vivo, impacting
- Author
- Apu kumar Das
- Language
- EN